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cardiac glycoside

" in MedChemExpress (MCE) Product Catalog:

21

Inhibitors & Agonists

17

Natural
Products

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-N4252
    Periplocymarin

    		Others Cancer
    Periplocymarin, a cardiac glycoside isolated from Periploca sepium and Periploca graeca, is a potential anti-cancer compound .
    Periplocymarin
  • HY-114252
    Strophanthidin

    		Na+/K+ ATPase Cardiovascular Disease
    Strophanthidin is a naturally available cardiac glycoside . Strophanthidin 0.1 and 1 nmol/L increases and 1~100 µmol/L inhibits the Na+/K+-ATPase activities, but Strophanthidin 10 and 100 nmol/L does not affect Na+/K+-ATPase activities in cardiac sarcolemmal . Strophanthidin increases both diastolic and systolic intracellular Ca 2+ concentration .
    Strophanthidin
  • HY-N8735
    k-Strophanthoside

    		Others Cardiovascular Disease
    k-Strophanthoside is a cardiac glycoside compound that can be isolated from the seeds of Strophanthus kombe .
    k-Strophanthoside
  • HY-N9149
    Cryptanoside A

    		Na+/K+ ATPase Akt NF-κB Cardiovascular Disease Inflammation/Immunology Cancer
    Cryptanoside A, a cardiac glycoside epoxide, can be isolated from the stems of Cryptolepis dubia. Cryptanoside A has potent cytotoxicity against cancer cells. Cryptanoside A also inhibits Na+/K+-ATPase activity. Cryptanoside A increases the expression of Akt and the p65 subunit of NF-κB .
    Cryptanoside A
  • HY-N12147
    Cannogenol 3-O-β-gentiobiosyl-(1→4)-α-L-thevetoside

    		Others Cancer
    Cannogenol 3-O-β-gentiobiosyl-(1→4)-α-L-thevetoside (Compound 12) is a cardiac glycoside that can be isolated from seeds of Thevetia peruvian. Cannogenol 3-O-β-gentiobiosyl-(1→4)-α-L-thevetoside shows cytotoxicity against SW1990 and MGC-803 cells (IC50: 9.52 and 7.70 μM) .
    Cannogenol 3-O-β-gentiobiosyl-(1→4)-α-L-thevetoside
  • HY-145154
    Digoxigenin monodigitoxoside

    		Na+/K+ ATPase Metabolic Disease
    Digoxigenin monodigitoxoside is a Na+/K+ ATPase inhibitor and cardiac glycoside metabolite of digoxin.
    Digoxigenin monodigitoxoside
  • HY-N12745
    3-Epigitoxigenin

    		Others Cardiovascular Disease
    3-Epigitoxigenin is a cardiac glycoside that can be isolated from the seeds of Strophanthus diuaricatus .
    3-Epigitoxigenin
  • HY-16022
    Acetyldigitoxin

    Digitoxin 3'''-Acetate

    		 Others Others
    Acetyldigitoxin (Digitoxin 3'''-Acetate) is a cardiac glycoside. Acetyldigitoxin can come from the leaves of Digitalis species. Acetyldigitoxin reduces the heart rate and can be used for cardiac failure rasearch .
    Acetyldigitoxin
  • HY-W671746
    Thevetin A

    		Others Others
    Thevetin A is a thevetia cardiac glycoside. Thevetin A can be isolated from the methanol extract of the seeds of Cascabela thevetioides .
    Thevetin A
  • HY-N12749
    16-Anhydro Digitalin

    		Others Cardiovascular Disease
    16-Anhydro Digitalin (compound 11) is a cardiac glycoside with a 16-dehydroisosyringyl aglycone structure .
    16-Anhydro Digitalin
  • HY-B2151
    Digitoxigenin

    Cerberigenin; Echujetin
    Digitoxigenin is a steroid derivative commonly found in various plants, especially the foxglove plant (Digitalis purpurea). Digitoxigenin has unique chemical properties that make it an important precursor for the synthesis of cardiac glycosides, a group of drugs used to improve heart failure and certain types of arrhythmias. It works by inhibiting the sodium potassium ATPase pump, thereby increasing the force and efficiency of cardiac contractions.
    Digitoxigenin
  • HY-B1030
    Lanatoside C
    4 Publications Verification

    		 Flavivirus Dengue virus Autophagy Enterovirus Cardiovascular Disease Cancer
    Lanatoside C is a cardiac glycoside, can be used in the treatment of congestive heart failure and cardiac arrhythmia.Lanatoside C has an IC50 of 0.19 μM for dengue virus infection in HuH-7 cells. Lanatoside C can effectively inhibit all four serotypes of dengue virus, flavivirus Kunjin, alphavirus Chikungunya, Sindbis virus and the human enterovirus 71 .
    Lanatoside C
  • HY-N1156A
    α-Thevetin B

    		Others Cardiovascular Disease Cancer
    α-Thevetin B（Compound 24） is a cardiac glycoside that can be isolated from Thevetia peruviana. α-Thevetin B（Compound 24） can be used in lung cancer, gastric cancer and pancreatic cancer research .
    α-Thevetin B
  • HY-111934
    Cymarin

    		Others Parasite Others Cancer
    Cymarin, a cardiac glycoside, potently inhibits the Palytoxin (PTX)-induced K + release (IC50=0.42 μM) . Cymarin reveals an antitumor activity against breast cancer and pancreatic cancer . Cymarin exhibits antifeedant and growth inhibitory effects as crop protectant .
    Cymarin
  • HY-A0154
    Deslanoside

    Deacetyllanatoside C; Desacetyllanatoside C
    Deslanoside (Desacetyllanatoside C) is a rapidly acting cardiac glycoside used to treat congestive heart failure and supraventricular arrhythmias due to reentry mechanisms, and to control ventricular rate in the treatment of chronic atrial fibrillation. Deslanoside inhibits the Na-K-ATPase membrane pump, resulting in an increase in intracellular sodium and calcium concentrations .
    Deslanoside
  • HY-N8441
    Neriifolin

    17β-Neriifolin

    		 Atg8/LC3 Na+/K+ ATPase Apoptosis Beclin1 Inflammation/Immunology Cancer
    Neriifolin, a CNS-penetrating cardiac glycoside, is an inhibitor of the Na +, K +-ATPase. Neriifolin can target beclin 1, inhibits the formation of LC3-associated phagosomes and ameliorates experimental autoimmune encephalomyelitis (EAE) development. Neriifolin induces cell cycle arrest and apoptosis in human hepatocellular carcinoma HepG2 cells [2.
    Neriifolin
  • HY-N12140
    2'-epi-2'-O-Acetylthevetin B

    GHSC-74

    		 Apoptosis Cancer
    2'-epi-2'-O-Acetylthevetin B (GHSC-74) is a cardiac glycoside that can be isolated from the seeds of Cerbera manghas L. 2'-epi-2'-O-Acetylthevetin B inhibits cell viability, induces apoptosis and loss of mitochondrial membrane potential in HepG2 cells .
    2'-epi-2'-O-Acetylthevetin B
  • HY-N2453
    Convallatoxin

    		PPAR NF-κB P-glycoprotein Inflammation/Immunology Cancer
    Convallatoxin is a cardiac glycoside isolated from Adonis amurensis Regel et Radde. Convallatoxin ameliorates colitic inflammation via activation of PPARγ and suppression of NF-κB. Convallatoxin is a P-glycoprotein (P-gp) substrate and recognized Val982 as an important amino acid involved in its transport. Convallatoxin is an enhancer of ligand-induced MOR endocytosis with high potency and efficacy. Anti-inflammatory and anti-proliferative properties .
    Convallatoxin
  • HY-N12143
    Acetylthevetin A

    		Others Others
    Acetylthevetin A is a natural product isolated from oleander (Cascabela thevetioides) .
    Acetylthevetin A
  • HY-N1441
    Afzelin
    2 Publications Verification

    Kaempferol-3-O-rhamnoside
    Afzelin (Kaempferol-3-O-rhamnoside)It is a flavonol glycoside that has anti-inflammatory, anti-oxidative stress response, anti-apoptotic, and anti-cardiac cytotoxic effects. AfzelinIt can reduce mitochondrial damage, enhance mitochondrial biosynthesis, and reduce mitochondria-related proteins. Parkinand PTENinduced putative kinase 1 (putative kinase 1)s level. AfzelinCan be improved D-galactosamine(GalN)/LPSSurvival rate of mice treated with doxorubicin prophylaxis (HY-15142A)Induced cardiotoxicity and scopolamine (HY-N0296)-induced neurological injury. AfzelinAlso inhibits asthma and allergies caused by ovalbumin .
    Afzelin
  • HY-N1156
    Thevetin B

    		Others Others
    Thevetin B (compound 1) is a betalain isolated from Thevetia peruviana .
    Thevetin B

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